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Cardiomyopathies (CMP) Cardiovascular disease risk in obese children and adolescents (CVD) Juvenile idiopathic arthritis (JIA) Neurological and neuromuscular diseases (NND)

 

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Infostructure

Since March 2017, MD-Paedigree integration platform is released.

V1.0

You can find related documents here :

 

 

MD-Paedigree repository implements all the functionalities, in line with the original estimated advancement. All partners worked in concordance to provide the most adapted and usable system to physicians. Current system is well sized for the project purpose but some non-technical aspects impacts the original assumption that all gateways could be stored on OPBG PCDR system. Cloud and GPU integrations are done and ready to be used, but no funds have been planned for infrastructure empowerment, so the consortium will have to find a way to provide these resources if modelling challenges are submitted to the system.

The decision to use agile methodology, as described in D17.1 has not been enabled but agility concepts have been applied resulting in better communication and understanding between the infostrucure group, physician and modellers. This better communication and synchronisation between software providers and users  improves the project's efficiency, resulting in a user-oriented system ready to be used.

All the functionalities are present and all the data modalities have been imported.

Integration of different partners application has occured and became fully integrated as part of the infostructure.

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Infrastructure

This figure illustrates how the resulting PCDR infrastructure could look like after the full execution of PCDR deployment. It is based on a mixed usage of the proposed Distributed Architecture (DA) and Hybrid Architecture (HA), where DA sites are automatically replicated with transactions guarantying databases' integrity, whereas HA sites do access their corresponding DA provider (Hub) to benefit from immediate storage and querying of networked data.


Thanks to gnúbila Pandora Private Cloud solution, OPBG Rome remains connected to the Health-e-Child and Sim-e-Child European excellence networks, from which it can access massive computing power, in particular, the European and American processing centres. Moreover, PCDR benefits from the (mandatory) central site Information System. OPBG thus capitalizes on these additional computing resources to setup its own network and to process greater volumes of medical data while opening a channel for migrating translational research applications to its production PCDR environment.


The pillars of this infrastructure lie in the two main sites, i.e. Rome and Taormina, which are both deployed using the DA solution. These two sites provide high quality of services upon accesses to the data by connected sites. Metropolitan sites, such as Palidoro, San Paolo and Santa Marinella host their own database and share with the rest of the OPBG network. On the other hand, the associated HA sites share and access the OPBG network throughout the two (respectively Roman and Sicilian) hubs. These hubs can also accept new connections from external sites, such as new collaboration hospitals and clinical centres interested in sharing data and accessing the state-of-theart in related research applications.